Changes

<nct_id>NCT00000102</nct_id>

</id_info>

<brief_title>Congenital Adrenal Hyperplasia: Calcium Channels as Therapeutic Targets</brief_title>

-<oversight_info>

<authority>United States: Federal Government</authority>

</oversight_info>

-<brief_summary>

<textblock> This study will test the ability of extended release nifedipine (Procardia XL), a blood pressure medication, to permit a decrease in the dose of glucocorticoid medication children take to treat congenital adrenal hyperplasia (CAH). </textblock>

</brief_summary>

-<detailed_description>

<textblock> This protocol is designed to assess both acute and chronic effects of the calcium channel antagonist, nifedipine, on the hypothalamic-pituitary-adrenal axis in patients with congenital adrenal hyperplasia. The multicenter trial is composed of two phases and will involve a double-blind, placebo-controlled parallel design. The goal of Phase I is to examine the ability of nifedipine vs. placebo to decrease adrenocorticotropic hormone (ACTH) levels, as well as to begin to assess the dose-dependency of nifedipine effects. The goal of Phase II is to evaluate the long-term effects of nifedipine; that is, can attenuation of ACTH release by nifedipine permit a decrease in the dosage of glucocorticoid needed to suppress the HPA axis? Such a decrease would, in turn, reduce the deleterious effects of glucocorticoid treatment in CAH. </textblock>

</detailed_description>

<overall_status>Completed</overall_status>

<phase>Phase 1/Phase 2</phase>

<study_type>Interventional</study_type>

<study_design>Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment</study_design>

<condition>Congenital Adrenal Hyperplasia</condition>

==== Location ====

The corresponding node is: